Workers may be harmed from exposure to antimony and its compounds. Arsenic trioxide may also be used for other purposes not listed in this medication guide. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. Antimony can also cause problems with the lungs, heart, and stomach. Identification Product Name Antimony(III) oxide Cat No. The state of California lists antimony trioxide as a chemical known to cause cancer. The primary hazard is the threat to the environment. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Pentavalent antimony compounds have been used for the treatment of leishmaniasis. Get the latest public health information from CDC and research information from NIH. (di)antimony trioxide 1309-64-4 >98.0 lead monoxide 1317-36-8 <0.1% (di)arsenic trioxide 1327-53-3 <0.1% Section 4 - First Aid Measures Description of necessary measures, subdivided according to the different routes of exposure: General advice: If exposed or concerned: Get medical advice/attention. The International Agency for Research on Cancer has concluded antimony trioxide is "possibly carcinogenic to humans" (IARC, 1989). level of evidence from cancer studies of antimony(III) trioxide in humans and experimental animals. Take off all contaminated clothing. Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. The HEEP for Antimony Oxides (U.S. EPA, 1985) and HEA for Antimony and Compounds (U.S. EPA, 1987) acknowledged there was suggestive evidence 888-232-6348 (TTY) *Antimony Trioxidemay be a CARCINOGEN in humans since it has been shown to cause lung cancer in animals. Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. Reports on Peer Reviews for the Report on Carcinogens. Chemical compounds based on antimony are used as pigments – one of them, antimony trioxide is also used as a flame retardant in textiles and plastics. Status: Cancer hazard evaluation for potential listing in the Report on Carcinogens (RoC) Primary Uses or Exposures Oxide of trivalent (+3) antimony and … SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. The Department of Health and Human Services (HHS) considers antimony trioxide to be reasonably anticipated to be a human carcinogen (causing cancer in people). EPA has not classified antimony for carcinogenicity. Antimony(III) oxide is the inorganic compound with the formula Sb 2 O 3.It is the most important commercial compound of antimony.It is found in nature as the minerals valentinite and senarmontite. WARNING: This product can expose you to antimony trioxide, which is known to the State of California to cause cancer. Before sharing sensitive information, make sure you're on a federal government site. RESULTS:In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working … It is used to fireproof fabrics, paper and plastics, as a paint pigment and for many other uses. Antimony (Sb) is a silver-white brittle solid or a dark-gray, lustrous powder. Date of Listing: 10/01/1990. Primarily used as a synergist for halogenated flame retardants in plastics, rubber, and textiles, all of which are used in a wide variety of consumer products. In addition, the available mechanistic and other relevant data (such as disposition and toxicokinetics) are assessed, and the final listing recommendation is based on an integration of all the relevant information (as summarized in the table above). Ahmed Mostafa, MD, Ryan Surmaitis, DO, Maricel Dela Cruz, DO, Michael Greenberg, MD, Muhammad Khalid, MD, Division of Medical Toxicology at Drexel University College of Medicine, Caroline Braibant on behalf of the International Antimony Association, RoC Monograph- Final (correction posted April 4 2019), Process for Preparing the Draft RoC Monograph on Antimony Trioxide and Charge, Oral Comments:  Mrs. Rita Cortvrindt, Campine, Revised Draft Report on Carcinogens Monograph on Antimony Trioxide, Revised Draft Report on Carcinogens Monograph on Helicobacter pylori (Chronic Infection), BSC’s Perspective for NTP Regarding Strategic Realignment, Caroline Braibant, Geert Krekel, Nathalie Branche. Supplemental materials for events, meetings, and workshops prior to 2017 have been archived. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide Occurence(s)/Use(s) Component of flame retardant treatment for polymers; opacifying agent for glasses, ceramics, and enamels; specialty pigments; naturally occurring as valentinite and senarmontite Human studies are inconclusive regarding antimony exposure and cancer, while animal studies have reported lung tumors in rats exposed to antimony trioxide via inhalation. This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. Can I get a medical test to check for antimony? Chemical Status; Cancer: Currently listed. People are mainly exposed to antimony trioxide in the workplace. What is antimony trioxide? Arsenic trioxide is sometimes given in combination with another medicine called tretinoin. Groth DH, Stettler LE, Burg JR, Busey WM, Grant GC, Wong L. This study was initiated because of a suspected increase in incidence of lung cancer in antimony smelter workers in England. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Exposure to antimony trioxide may increase the risk of cancer. Cancer; Listed as causing: Cancer. Cancer: 10/01/1990. The International Agency for Research on Cancer has determined that antimony trioxide is possibly carcinogenic to humans and that antimony trisulfide is not classifiable. However, if you come into contact with actual antimony dust, you can experience symptoms like depression, dizziness, headaches, vomiting, kidney damage, or liver damage. It can be harmful to the eyes and skin. Antimony potassium tartrate has been used worldwide as an anti-shistosomal drug. It is insoluble in water. Breathing air contaminated with antimony can cause eye and lung irritation, heart and lung damage, stomach pains, diarrhea, vomiting, and stomach ulcers. Email: Contact CDC-INFO. The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. How can I protect myself and my family from antimony? Antimony trioxide was tested for carcinogenicity by inhalation exposure in male and female rats of one strain and in female rats of another strain, producing a significant increase in the incidence of lung tumours (scirrhous and squamous- cell carcinomas and bronchioloalveolar tumours) in … Reprotoxicity In the Russian literature women occupational exposed to antimony aerosols were reported to have a higher incidence of spontaneous abortion, premature births and menstrual disorders. What happens when I eat or breathe antimony? Antimony trioxide is classified as a carcinogen in the state of California. Oxide of trivalent (+3) antimony and most commercially significant form of antimony. Antimony trioxide is a white crystalline solid. However, there are companies in the United States that produce antimony … Inhalation (Particles) The average room-air concentration and average exposure concentration for antimony trioxide were obtained as described for the noncancer risk assessment of particles. It is brought into this country from other countries for processing. Antimony trioxide is a mild primary eye irritant in rabbits. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. Antimony trioxide was last classified by the International Agency for Research on Cancer (IARC) in 1989 as Group 2B, possibly carcinogenic to humans, based on inadequate evidence in humans and sufficient evidence in animals. Note: Javascript is disabled or is not supported by your browser. These clinics specialize in An increased lung cancer risk cannot be excluded. Antimony sesquioxide; Antimonous oxide; Antimony oxide, Oxo-oxostibanyloxystibane; Diantimony trioxide . Basis for Listing AB-IARC. Results: In typical case scenarios, the occupational cancer risk from antimony trioxide was estimated to be 0.025 (25 in 1000) for persons working with flame retardants in plastics and textiles for 40 years. Evidence for lung neoplasms caused by antimony trioxide inhalation in e … Antimony trioxide is a respiratory carcinogen in female rats. Federal government websites often end in .gov or .mil. Email us or use our contact form to request a list or copy of archived materials for the following meeting. One compound — antimony trioxide — is even believed to be carcinogenic, and antimony poisoning has also been known to lead to Adams-Stokes syndrome. The .gov means it's official. potential concern for human health based on its classification by international organizations as a substance that was found to cause cancer in laboratory animals ATSDR can also tell you the location of occupational and environmental health clinics. Uses advised against Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet An official website of the United States government. For assistance, email us or use our contact form and identify the documents/pages for which access is required. Typical and worst-case inhalation scenarios in multiple occupational settings were used in risk estimation. Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. Chemical Listing Details. Caroline Braibant - Human Health: Genotoxicity, Caroline Braibant - Human Health: Lung Toxicity and Carcinogenicity, Testing Status of Antimony Trioxide 10676-V, National Institute of Environmental Health Sciences, Federal Register notice requesting public comment on nominated substances (, Division of Medical Toxicology at Drexel University College of Medicine. For this reason, some items on this page will be unavailable. Little antimony is currently mined in the United States. Fact Sheets; ANTIMONY TRIOXIDE 256 Cancer There are inadequate data to assess the carcinogenicity of antimony trioxide from dermal or oral exposures. This is only a partial list; employers are obliged to prevent the exposure of these workers to any agents that may cause adverse health effect for either mother or child. They can potentially be exposed when using consumer products containing antimony trioxide or breathing contaminated air. These archived materials frequently include presentations, background materials, and public comments. Antimony is toxic and several states have identified it as a safety concern for children’s products. Rat oral LD 50 >34 g kg −1. Antimony carcinogenicity evidence involving workers is inadequate, based on confounding, small sample sizes, incomparability across studies, and inadequate reference populations. Cal EPA. The level of exposure depends upon the dose, duration, and work being done. The in vivo genotoxicity of antimony trioxide was studied using single and repeat dose mouse bone marrow micronucleus tests, and the rat liver unscheduled DNA synthesis assay. Antimony is a silvery-white metal that is found in the earth's crust. All three studies were negative. Antimony trioxide is a compound used in the production of certain flame retardants and other industrial processes. In 1989, the International Agency for Research on Cancer (IARC) concluded that Diantimony Trioxide is possibly carcinogenic to humans (Group 2B), and Antimony Trisulfide is not classifiable with regards to its carcinogenicity to humans (Group 3). Ahmed Mostafa, M.D., Ryan Surmaitis, D.O., Maricel Dela Cruz, D.O., Michael Greenberg, M.D., Muhammad Khalid, M.D. A cancer assessment for antimony trioxide is not available on IRIS (U.S. EPA, 2008) or in the HEAST (U.S. EPA, 1997). Antimony trioxide is on the Proposition 65 list because it can cause cancer. NIEHS has helpful information on accessibility. Like most polymeric oxides, Sb 2 O 3 dissolves in aqueous solutions with hydrolysis.A mixed arsenic-antimony oxide occurs in the nature as the very rare mineral stibioclaudetite. The site is secure. 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